CARCINOEMBRYONIC ANTIGEN EXPRESSION IN GASTRIC CANCER AS.RELATED TO BIOLOGICAL BEHAVIOUR AND PROGNOSIS*
Abstract
Objective: To determine the relationship between carcinoembryonic antigen (CEA) expression in gastric cancer and biological behaviour or prognosis.
Material and Methods: Surgically resected specimens of gastric cancer from 104 patients were obtained. The content and distribution of CEA in gastric cancer were studied by immunohistochemical staining and immunoelectron microscopic technique. The relationship between CEA in gastric cancer and biological behaviour or prognosis were evaluated.
Results: The positivity of CEA was significantly higher in the patients with advanced stage, vascular invasion and lymph node metastasis than that in the patients without. The 5-year survival rate of the CEA (-) group was significantly higher than that of the CEA (+) group. Among the patients with advanced stage or lymph node metastasis, the survival rate was higher in the CEA (-) group than in the CEA (+) group.
Conclusions: lmmunostaining for CEA in gastric cancer tissue may be helpful in differentiating among tumors that appear similar by conventional histological methods, thus providing a new means for discernment of invasion, metastasis and prognosis of gastric cancer.
Material and Methods: Surgically resected specimens of gastric cancer from 104 patients were obtained. The content and distribution of CEA in gastric cancer were studied by immunohistochemical staining and immunoelectron microscopic technique. The relationship between CEA in gastric cancer and biological behaviour or prognosis were evaluated.
Results: The positivity of CEA was significantly higher in the patients with advanced stage, vascular invasion and lymph node metastasis than that in the patients without. The 5-year survival rate of the CEA (-) group was significantly higher than that of the CEA (+) group. Among the patients with advanced stage or lymph node metastasis, the survival rate was higher in the CEA (-) group than in the CEA (+) group.
Conclusions: lmmunostaining for CEA in gastric cancer tissue may be helpful in differentiating among tumors that appear similar by conventional histological methods, thus providing a new means for discernment of invasion, metastasis and prognosis of gastric cancer.