GENE EXPRESSION OF TRANSFORMING GROWTH FACTOR β1 TYPE II RECEPTOR IN HCC AND ITS CLINICAL SIGNIFICANCE
Abstract
Objective: Transforming Growth Factor-[βl (TGF-[β1) plays a central role in the process of growth suppression ,if the hepatocytes, and its type II receptor (TGF-β1R II) transfers the signal of growth suppression. In this study, the gene expression of TGF-[β1R II in HCC and its clinical significance was investigated.
Methods: The expression of TGF-[β1R II mRNA in 30 cases of HCC tissue and the surrounding liver tissue was separately detected using reverse transcription-PCR.
Results: The positive expression rate of TGF-[β1R II mRNA was significantly lower in HCC tissue (11/30) than that in the surrounding liver tissue (23/30) (P<0.01). Further, the less the cancer tissue expressed TGF-[β1R II mRNA, the more poorly the tumoral hepatocyte differentiated (P<0.01) and the more portal vein cancer embolus existed (p=0.0465).
Conclusion: The decrease expression of TGF-[β1R II mRNA by tumoral hepatocyte results in the defect of its negative growth regulation, and this may be one of the most important reasons for its carcinogenesis and uncontrolled growth.
Methods: The expression of TGF-[β1R II mRNA in 30 cases of HCC tissue and the surrounding liver tissue was separately detected using reverse transcription-PCR.
Results: The positive expression rate of TGF-[β1R II mRNA was significantly lower in HCC tissue (11/30) than that in the surrounding liver tissue (23/30) (P<0.01). Further, the less the cancer tissue expressed TGF-[β1R II mRNA, the more poorly the tumoral hepatocyte differentiated (P<0.01) and the more portal vein cancer embolus existed (p=0.0465).
Conclusion: The decrease expression of TGF-[β1R II mRNA by tumoral hepatocyte results in the defect of its negative growth regulation, and this may be one of the most important reasons for its carcinogenesis and uncontrolled growth.