EXPRESSION OF c-erbB-2 AND PCNA IN CERVICAL ADENOCARCINOMA AND ITS SIGNIFICATION
Abstract
Objective: To investigate the significance of cerbB- 2 and PCNA expression in adenocarcinoma.
Methods: Expression of c-erbB-2 and PCNA in 74 cases of adenocarcinoma of the uterine cervix was examined by immunohistocbemistry.
Results: The expression of cerbB- 2 was detected in 34 cases. The positive staining of c-erbB-2 was associated with increased lymph node metastasis (57.1% vs 24.0%, P--0.041) and lower 5-year survival rate (32.4% vs 58.9%, P--0.008). The average PCNA labeling index (PCNA LI) was 40.6% (0.1%- 91.4%). High PCNA LI was associated with lymph node metastasis (56.4% vs 38.5%, P--0.016) and lower 5-year survival rate (28.7% vs 64.4%, P=0.005). Positive staining of c.erbB.2 were associated with high PCNA LI (44.7% vs 34.6% P=0.003).
Conclusions: c-erbB-2 and PCNA LI were associated with malignant biological behavior and poor prognosis of patients with cervical adenocarcinoma.
Methods: Expression of c-erbB-2 and PCNA in 74 cases of adenocarcinoma of the uterine cervix was examined by immunohistocbemistry.
Results: The expression of cerbB- 2 was detected in 34 cases. The positive staining of c-erbB-2 was associated with increased lymph node metastasis (57.1% vs 24.0%, P--0.041) and lower 5-year survival rate (32.4% vs 58.9%, P--0.008). The average PCNA labeling index (PCNA LI) was 40.6% (0.1%- 91.4%). High PCNA LI was associated with lymph node metastasis (56.4% vs 38.5%, P--0.016) and lower 5-year survival rate (28.7% vs 64.4%, P=0.005). Positive staining of c.erbB.2 were associated with high PCNA LI (44.7% vs 34.6% P=0.003).
Conclusions: c-erbB-2 and PCNA LI were associated with malignant biological behavior and poor prognosis of patients with cervical adenocarcinoma.