SIGNIFICANCE OF EXPRESS OF SOME NONHORMONAL ANTIGENS IN PANCREATIC ENDOCRINE TUMORS
Abstract
Objective: To study the express of some nonhormonal antigens in pancreatic endocrine tumors.
Methods: The nonhormonal antigens including AIpha-subunit of human chorionie gonadotropin (α-HCG), progesterone receptors (PR), 7B2, HISL-19, in normal pancreatic islets and in 52 cases of pancreatic endocrine tumors (PET) were investigated by immunohistochemistry.
Results: It was found that HCG can be detected in PET but not in normal islet cells. HCG immunoreactivity was expressed by 3 of 28 (10.7%) benign PET and by 14 of 24 (58.3%) malignant PET. PR was found by 20 of 28 (71.4%) benign PET and by 7 of 24 (29%) malignant PET. 7B2 was detected by 23 of 28 (82.1%) benign PET and by 13 of 24 (54.2%) malignant PET. HISL-19 was appeared by 23 of 28 benign PET and by 11 of 24 (46%) malignant PET. Golgitype persisted in 87.5% malignant tumors.
Conclusion: The assay of nonhormonal antigens may be well defined the clinico-pathological characteristics of PET.
Methods: The nonhormonal antigens including AIpha-subunit of human chorionie gonadotropin (α-HCG), progesterone receptors (PR), 7B2, HISL-19, in normal pancreatic islets and in 52 cases of pancreatic endocrine tumors (PET) were investigated by immunohistochemistry.
Results: It was found that HCG can be detected in PET but not in normal islet cells. HCG immunoreactivity was expressed by 3 of 28 (10.7%) benign PET and by 14 of 24 (58.3%) malignant PET. PR was found by 20 of 28 (71.4%) benign PET and by 7 of 24 (29%) malignant PET. 7B2 was detected by 23 of 28 (82.1%) benign PET and by 13 of 24 (54.2%) malignant PET. HISL-19 was appeared by 23 of 28 benign PET and by 11 of 24 (46%) malignant PET. Golgitype persisted in 87.5% malignant tumors.
Conclusion: The assay of nonhormonal antigens may be well defined the clinico-pathological characteristics of PET.