From February to September in 1994, a total of 58 patients with nasopharyngeal carcinoma (NPC) were testified by pathology. It included 56 poorly differentiated squamous cancer, 1 poorly differentiated adenocarcinoma , 1 B-cell lymphoma. Clinical staging: II stage 6 cases, lII stage 20 cases, IV stage 24 cases, recurrence 8 cases. The results showed that ER and PR positive rate were 26/58 (44.8%) and 28/58 (48.3%). The rate has not relation to the age and sex. There was a contrary rela-tion between ER, PR positive rate and clinical staging and VCA-IgA. When ER, PR were negative and VCA-IgA was 1:40 in IV stage patients, its accorded rate was 9/12 (75%); when only VCA-IgA was 1:40, accorded rate was 13/33 (39.4%). Total CR was 38/49 (77.6%). When both ER and PR were positive, CR was 79%; when both ER and PR were negative and VCAIgA was 1:40,CR was 58.3%. We regard NPC is belong to high expression tumor of estrogen and progesterone, and positive expression can reflect tumor developing tendency and relate to recent prognosis. The paper suggests that it is possible to treat NPC with the endocrine therapy. Examining ER, PR and VCA-IgA together can improve the analysis of the prognosis ofNPC.