Analysis of 2547 cases of multiple myeloma (MM) reported in China in 1980s showed that the clinical manifestations are characterized by multipliey, iligh misdiagnosis rate (69%) and multiple complications. while the monoclonal protein had more than 25 immunological types, lgG myeloma was the commonest (43.1%). Light chain subgroup trended to have a higher incidence of renal demage (76.9%). Plasma cell leukemia evenetually developed in 30 cases. In order to improve diagnosis and avoid misdiagnosis, the key points are l, to better the recognition of clinical features of MM. 2. Patient should receive urine Bence-Jones protein, immunoglobulins, immunoelectrophresis, bone X-ray and multiple site bone marrow puncture whenever one of such manifestations as unexplained anemia, skeletal pain, proteinuria, elevation of ESIL hyperviscosity syndrome, hypercalcemia, hyperuricemia, elevation of alkaline phosphatase, pathological fractures and diffuse osteoporosis, 3. Immuno-binding electrophoresis and immunolluorence antibody detection should be done for suspected cases with normal immunoglobulin level.