64 patients with unresectable cancer of the pancreatic head were admitted in our hospital form 1989 to 1995. 21 cases were treated by radiotherapy (Group A). 23 cases were treated by cholecystojejunostomy or choledojejunostomy (Group B). 20 cases were treated by cholecystojejunostomy or choleeystojejunostomy combined with superior panreatocoduodenal artery ADM, 5-Fu perfusion with multifunctional implantable drugdelivery system and radiotherapy (Group C). The l-year survival rates of these three groups were 0%, 0% and 4% respectively. The authors believe that combined treatment of Group C is recommended for unresectable cancer of the pancreatic head.