Polymorphisms of XPC Gene And Susceptibility of Esophageal Cancer
Abstract
Objective: To explore the relationships of the polymorphisms of xeroderma pigmentosum C (XPC) and the susceptibility of esophageal cancer (EC) in Changzhi area, China.
Methods: The study was conducted by a case-control study which included 196 cases of EC and 201 cases of controls. XPC PAT polymorphisms were determined with polymerase chain-restriction on fragment length polymorphism (PCR-RFLP).
Results: The frequencies of wild homozygote (PAT−/−), mutation heterozygote (PAT−/+) and mutation homozygote (PAT+/+) of XPC were 36.73%, 51.53% and 11.74% in case group, 37.81%, 52.24% and 9.95% in control group, respectively, and there was no significant difference between the two groups (χ2 =0.332, P=0.847). There was no interaction between XPC PAT mutation genotype and xeroderma pigmentosum A (XPA) (S=0.85) and pickled food (S=0.81).
Conclusion: A genetic polymorphism in XPC may be not associated with esophageal cancer in Changzhi population.
Methods: The study was conducted by a case-control study which included 196 cases of EC and 201 cases of controls. XPC PAT polymorphisms were determined with polymerase chain-restriction on fragment length polymorphism (PCR-RFLP).
Results: The frequencies of wild homozygote (PAT−/−), mutation heterozygote (PAT−/+) and mutation homozygote (PAT+/+) of XPC were 36.73%, 51.53% and 11.74% in case group, 37.81%, 52.24% and 9.95% in control group, respectively, and there was no significant difference between the two groups (χ2 =0.332, P=0.847). There was no interaction between XPC PAT mutation genotype and xeroderma pigmentosum A (XPA) (S=0.85) and pickled food (S=0.81).
Conclusion: A genetic polymorphism in XPC may be not associated with esophageal cancer in Changzhi population.