One case of small-cell carcinoma (SCC) of prostate was identified at Shangyu people’s hospital. This 70-year-old male had a prior diagnosis of prostatic adenocarcinoma when he was first admitted to the hospital and received anti-androgen treatment. 9 months later, he was readmitted to the hospital and was diagnosed as SCC through biopsy. The article was written to evaluate the clinical and pathological characteristics and treatment of SCC of prostate.