Seventy-four cases of colonic cancer were studied by immunohistochemistry using anti-Chromogranin A, gastrin, somatostatin, serotonin, glucogon and human chorionic gonadotropin (HCG) to observe the neuroendocrine cell in colonic cancer. It was found that 27 of 74 colonic carcinoma showed variable extent of CgA staining (36.50). Glucagon and HCG was differently the most frequent in hormone antigens in colonic cancer and in metastatic lymph nodes. The endocrine positive colonic carcinomas are more frequent in poorly-differentiated than in well-differentiated (P<0.05). It suggests that there were different NE cells producing different hormones in colonic cancer. Different hormones may act on different types of colonic cancer.